Brand Name: Zoloft (not available in generic)

Manufacturer: Roerig Division of Pfizer, Inc.

Description: Sertraline is an antidepressant in the class known as SSRIs (selective serotonin reuptake inhibitors).  Mechanism of action is thought to be linked to its inhibition of the central nervous system neuronal uptake of serotonin.

Indications and Uses: Sertraline is indicated for the treatment of depression, obsessive compulsive disorder, and panic disorder.

Contraindications, Warnings and Precautions: Sertraline may not be taken with MAOI's (monoamine oxidase inhibitors). It may activate mania in patients with Bipolar Disorder/Manic Depression. It should be used with caution in patients with a seizure disorder. Sertraline is contraindicated during pregnancy. It is not known if it is excreted in human breast milk, hence caution should be exercised in prescribing it to nursing mothers. Adverse effects are possible with other drugs which are also tightly bound to protein (e.g. warfarin, digitoxin, cimetidine). Caution is advised in administering Sertraline with other CNS (central nervous system) active drugs. Use with alcohol is not recommended. Safe use in children has not been established.

Adverse Reactions: The most common side effects are gastrointestinal (nausea, diarrhea/loose stools and dyspepsia). Other side effects may include tremor, dizziness, insomnia, increased sweating, delayed ejaculation in men and difficulty having an orgasm in women.

Dosing Range: Initial dose is usually 50 mg once a day.  Zoloft may be titrated to a maximum of 200 mg once a day.  Dosage increases should be no more frequent than weekly.

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007