Chemical Name:       Diazepam

Brand Name:             Valium

Manufacturer:           Roche

 

Description:            A benzodiazepine that probably acts on the limbic system, thalamus and hypothalamus of the central nervous system to produce calming effects.

Indications and Use:  Indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.  Valium may be useful in acute alcohol withdrawal.  Valium is useful in adjunctive treatment for the relief of skeletal muscle spasm due to reflex spasm to local pathology, spasticity caused by upper motor neuron disorders, athetosis and Stiff man syndrome.  Valium may also be used adjunctively in convulsive disorders.

Contraindications, Warnings and Precautions:  Contraindicated in patients with acute narrow angle glaucoma.  Caution should be used when driving or in hazardous occupations that require complete mental alertness.  When Valium is used as an adjunct treatment for convulsive disorders, abrupt withdrawal may be associated with a temporary increase in the frequency and/or severity of seizures.  An increased risk of congenital malformation in the first trimester of pregnancy has been suggested in several studies of this type of drug.  If Valium is to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be used, particularly with compounds known to potentiate the action of Valium, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants.  Use cautiously in the elderly.  Do not use with alcohol or other central nervous system depressants.  Use cautiously in depressed patients.  As with other benzodiazepines, caution must be used in persons known to be addiction-prone or persons whose history suggests likelihood they might increase the dose on their own initiative.  Withdrawal symptoms have occurred following the abrupt discontinuation of diazepam.

Adverse Reactions:  Possible common side effects may include drowsiness, fatigue and ataxia. Less common side effects may include slurred speech, headache, hallucinations, blurred vision, nausea, constipation, hypotension, urinary retention and altered libido.

Dosing Range:  Dosage should be individualized according to reason for use and age of patient.

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007