Brand Name: Trilafon (available in generic)

Manufacturer: Schering Corporation

Description:  Trilafon acts with all levels of the central nervous system, particularly the hypothalamus.  Its therapeutic mechanism of action is unknown.

Indications and Use: Trilafon is indicated for the management of the manifestations of psychotic disorders.  It is also used to control severe nausea and vomiting in adults.

Contraindications, Warnings, and Precautions: Contraindicated in patients that are comatose and patients who are receiving large doses of central nervous system depressants. Also contraindicated in patients with suspected or established subcortical brain damage. Trilafon may cause tardive dyskinesia, which is a potentially irreversible, involuntary syndrome that causes dyskinetic movements. Tardive dyskinesia is most prevalent in the elderly, particularly females. The potentially fatal symptom of Neuroleptic Malignant Syndrome (NMS) has been reported in association with anti-psychotic drugs. Signs of NMS include muscle rigidity, altered mental status, high fever, increase blood pressure, increased heart rate, and cardiac dysrhythmia. Trilafon may lower the seizure threshold in susceptible persons. Patients undergoing surgery must be monitored closely due to Trilafon's hypotensive effects. Alcohol should be avoided completely with this medication.

Adverse Reactions: Possible common side effects are extrapyramidal symptoms, orthostatic hypotension, blurred vision, dry mouth, constipation, urinary retention and mild photosensitivity. Less common side effects include sedation, dizziness, tachycardia, and inhibited ejaculation.

Dosing Range: Between 4 and 16mg up to 4 times per day. Do not exceed 64mg per day. Higher doses are associated with increased extrapyramidal symptoms.

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007