Chemical Name: Topiramate
Trade Name: Topamax
Manufacturer: Ortho-McNeil
Description: Mechanism of action is unknown. Thought to block action potential, suggestive of a sodium channel blocking action.
Indication: Topamax is FDA approved for the treatment of seizures. May also be used to stabilize mood in patients with Bipolar Disorder (Manic Depression). There is no FDA approval for this use.
Contraindications, Warnings, and Precautions: Do not take Topamax with other carbonic andydrase inhibitors. Topamax tablets should not be cut in half, they have a special coating, which should not be broken. Do not drink alcohol while taking this drug. Do not operate heavy machinery if taking Topamax it causes excessive drowsiness. Notify your doctor if you are pregnant or think you may be (note: Topamax may REDUCE the effectiveness of oral contraceptives). Drink plenty of water to prevent possible kidney stone formation.
Adverse Reactions: Possible side effects may include drowsiness, fatigue, tremor, weight loss, abnormal vision, dizziness, nausea, confusion, ataxia, nervousness, difficulty with memory, psychomotor slowing, somnolence, speech disorders, nystagmus, parasthenia, and upper respitory infection.
Dosing Range: The usual dosing range is between 200 mg to 800 mg per day, usually given twice a day.
