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Chemical
Name:
Chlorpromazine Brand
Name:
Thorazine Manufacturer:
SmithKline
Beecham Description:
A dimethylamine derivative of phenothiazine.
Mechanism of action is unknown. The
principle pharmacological actions are psychotropic. Indications
and Use: For
the management of the manifestations of psychotic disorders, to control nausea
and vomiting, relief of intractable hiccups, acute intermittent porphyria,
relief of restlessness and apprehension before surgery, the manifestations of
mania and severe behavior problems in children. Contraindications,
Warnings and Precautions:
Contraindicated
in patients in comatose states or in the presence of large amounts of central
nervous system depressants. The extrapyramidal symptoms that can occur secondary
to Thorazine may be confused with the signs of an undiagnosed primary disease
responsible for the vomiting such as Reye’s Syndrome or other encephalopathy.
Thorazine and other potential hepatotoxins should be avoided in children
and adolescents whose signs and symptoms suggest Reye’s Syndrome.
The potentially fatal symptom complex of Neuroleptic Malignant Syndrome (NMS)
has been reported in association with this class of drugs.
Signs of NMS include muscle rigidity, altered mental status, high fever,
increased blood pressure, increased heart rate and cardiac dysrhythmia.
Tardive Dyskinisia (TD) is a potentially irreversible, involuntary
movement that may develop. The
highest prevalence of TD is in the elderly, particularly women.
Safety for use during pregnancy has not been established.
Use cautiously in persons with cardiovascular, liver or renal disease as
well as persons with chronic respiratory disorders.
Thorazine can suppress the cough reflex; therefore, aspiration of vomitus
possible. Adverse
Reactions:
Possible common side effects may include extrapyramidal reactions,
orthostatic hypotension, sedation, dry mouth, constipation, urinary retention,
and mild photosensitivity. Other side effects may include drowsiness, dizziness,
blurred vision, nasal congestion, menstrual irregularities, gynecomastia,
inhibited ejaculation, lactation, priapism and abnormal liver function test
results. Dosing
Range:
Adjusted according to the individual and the severity of the condition.
For psychotic disorders, the dose should be increase gradually until
symptoms are under control. |
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These pages are solely for public informational purposes. The information cannot be relied on to make diagnoses or prescribe treatment in any individual. Persons who require such services should consult with a licensed professional. Send mail to ropa@redoakpsychiatry.com with questions or comments about this web site.© 2000 Red Oak Psychiatry Associates, P.A. Updated
11/26/2007
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