Brand Name: Serzone (not available in generic)

Manufacturer: Bristol-Myers Squibb

Description: Nefazodone is an antidepressant which is structurally different from the SSRIs (selective serotonin reuptake inhibitors), tricyclics, and MAOIs (monoamine oxidase inhibitors). It inhibits the reuptake of both serotonin and norepinephrine (neurochemical transmitters in the brain). 

Indications and Uses: Nefazodone is approved for use to treat depression.

Contraindications, Warnings and Precautions: It should not be given with terfenadine, astemizole, cisapride or MAOIs (monoamine oxidase inhibitors). It should not be co-administered with triazolam (Halcion) or aprazolam (Xanax) as it significantly increases the plasma concentrations of these medications. It should be used cautiously in patients with a history of mania. It is not known whether Nefazodone is excreted in breast milk. Caution should be exercised when prescribing it for nursing mothers. There are no controlled studies involving pregnant women.

Adverse Reactions: Possible common side effects leading to discontinuation of Nefazodone are: nausea, dizziness, insomnia, asthenia (muscle weakness), and agitation. Other possible side effects may be dry mouth, drowsiness, constipation, blurred vision, and confusion.

Dosing Range: The recommended starting dose is 200 mg per day in two divided doses. An effective dosing range is usually 300 to 600 mg per day, with dose increases no more frequent than weekly. 

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007