Chemical Name:  Quetiapine fumarate

 Trade Name:  Seroquel

 Manufacturer:  Zeneca, Inc.

 Description:  Mechanism of action unknown.  It is thought that this drug’s antipsychotic activity is mediated through a combination of dopamine type and serotonin type antagonism.

 Indication:  Seroquel is indicated for the management of the manifestations of psychotic disorders.

 Contraindications:   Tardive dyskinesia is a potentially irreversible involuntary movement that may develop.  The highest prevalence appears to occur in the elderly, especially woman.  There is no known treatment, although the syndrome may remit if antipsychotic treatment is withdrawn.  The potentially fatal symptom complex of Neuroleptic Malignant Syndrome (N.M.S.) has been reported in association with antipsychotic drugs.  Signs of N.M.S. may include hyperpyrexia, muscle rigidity, altered mental status, irregular pulse or blood pressure, tachycardia, sweating, and cardiac dysrhythmia.  Use with caution in patients with known cardiovascular disease, cerebrovascular disease, or conditions, which would predispose patients to hypotension such as dehydration, hypovolemia and treatment with antihypertensives.   The development of cataracts was observed in association with treatment in chronic dog studies.  Lens changes have also been observed in patients during long-term treatment, but a causal relationship to Seroquel has not been established.  Examination of the lens is recommended at initiation of treatment or shortly thereafter, and at 6 month intervals during chronic treatment.

 Adverse Reactions:  Possible common side effects may include dizziness, headache, and somnolence.

Less common side effects may include weight gain, orthostatic hypotension, tachycardia, palpitations, peripheral edema, dry mouth, and constipation.

 Dosing Range:  The usual dosing range is between 150 to 750mg per day.

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007