Chemical Name: Flupheanzine hydrochloride

Brand Name: Prolixin (available in generic)

Manufacturer: Apothecon

Description: An antipsychotic agent of an unknown mechanism.

Indications and Use: For the management of the manifestations of psychotic disorders.

Contraindications, Warnings, and Precautions: The potentially fatal symptom of Neuroleptic Malignant Syndrome (NMS) has been reported in association with this class of drugs. Signs of NMS include: muscle rigidity, altered mental status, high fever, increased blood pressure, increased heart rate and cardiac dysrhythmia. Tardive dyskinesia is a potentially irreversible, involuntary movement that may develop. The highest prevalence of tardive dyskinesia is in the elderly, particularly women. This medication has central nervous system effects; therefore, alcohol should be avoided. Prolixin is not intended for use in children under the age of 12 years. Use cautiously in patients exposed to extreme heat or phosphorous insecticides, in patients with a history of convulsive disorders, and in patients undergoing surgery due to the possibility of hypotensive effects.

Adverse Reactions: Possible side effects include extrapyramidal symptoms, tardive dyskinesia, orthostatic hypotension, blurred vision, dry mouth, constipation, urine retention, and mild photosensitivity. Abrupt withdrawal may cause gastritis, nausea and vomiting, dizziness, tremors, sweating, headache and insomnia.

Dosing Range: Varies with age of the patient and severity of symptoms.

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2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007