Brand Name: Norpramin (available in generic)

Manufacturer: Hoechst Marion Roussel

Description: Desipramine is an antidepressant in the tricyclic class. Although the precise mechanism of action is unknown, the theory is that tricyclic antidepressants restore normal levels of neurotransmitters (brain chemicals) by blocking their reuptake from the space between nerve endings (synapse). Desipramine appears to work primarily on norepinephrine. 

Indications and Uses: Desipramine is indicated for the treatment of depression. It is also used at lower doses to treat anxiety symptoms. Some physicians have used it to treat ADHD (Attention Deficit Hyperactivity Disorder).

Contraindications, Warnings, and Precautions: Desipramine may not be given within two weeks of treatment with an MAOI (Monoamine Oxidase Inhibitor). It is contraindicated during recovery from a heart attack. It should not be used in patients with a known hypersensitivity. Extreme caution should be used in giving desipramine to patients with known cardiovascular disease because it can affect the electrical conductivity of the heart. Desipramine has anticholinergic side effects and, therefore, should be used with caution in patients with urinary retention or glaucoma. Desipramine has been shown to lower the seizure threshold in patients with a history of seizure disorder. Safety for use in pregnancy or in nursing mothers has not been established. Desipramine should be used with caution with other medications acting on the same enzyme system. 

Adverse Reactions: Possibe common side effects include dry mouth, constipation, and nausea. It may also cause dizziness, urinary retention, hypotension, insomnia, and tremors. Stopping it abruptly after prolonged treatment may cause rebound symptoms - nausea, headache, and malaise. It is not addictive.

Dosing Range: The usual adult dose is 100 to 200 mg per day. If needed, dosing may progress up to 300 mg per day. Blood levels are recommended. Elderly patients and adolescents may require lower doses. 

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007