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Chemical Name: Phenelzine Sulfate Brand Name: Nardil Manufacture: Mylan Description: Mechanism of action unknown. An MAO inhibitor that probably promotes accumulation of neurotransmitters by inhibiting their metabolism. Indication and Use: Nardil is used in the treatment of depression. It should rarely be the first antidepressant drug used. It is more suitable for patients who have failed to respond to more commonly used antidepressants. Contraindications, Warnings, and Precautions: Contraindicated in patients with hypersensitivity to the drug, congestive heart failure, pheochromocytoma, hypertension, significant renal impairment, cerebrovascular defects, liver disease, or cardiovascular disease. Do not take sympathomimetic drugs, including amphetamines, cocaine, methylphenidate (Ritalin), dopamine, epinephrine, and norepinephrine or related compounds because use with MAO inhibitors may result in a hypertensive crisis, which has sometimes been fatal and are characterized by occipital headache, palpitation, neck stiffness and soreness, nausea, vomiting, sweating, dilated pupils and photophobia. Hypertensive crises may also be caused by the ingestion of foods that have a high concentration of tyramine or dopamine, so high protein foods that have undergone protein breakdown by aging, fermentation, pickling, smoking or bacterial contamination must be avoided. Some other foods to avoid are cheeses, yogurt, pickled herring, beer (including non alcoholic), wine, liver, yeast extract, dry sausage, fava beans and chocolate. Cottage cheese and cream cheese are allowed. Do not use with or within 10 days of Buspar or serotoninergic agents. At least 5 weeks should elapse between the discontinuation of Prozac and initiation of Nardil. Do not use with Wellbutrin or within 14 days of each other. Patients on Nardil should not have elective surgery requiring general anesthesia. Discontinue at least 10 days before elective surgery. Adverse Reactions: Possible side effects may include dizziness, vertigo, headache, insomnia, postural hypotension, anorexia, constipation, dry mouth, elevated serum transaminases, weight gain, sexual disturbances and drowsiness. Dosing Range: In adults 15 mg three times a day, increased rapidly to 60 mg daily according to patients tolerance. Maximum dosage is 90 mg daily. After maximum benefit is achieved the dosage can usually be reduced slowly over a few weeks. Maintenance dose may be as low as to 15 mg/day and should be continued as long as required.
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These pages are solely for public informational purposes. The information cannot be relied on to make diagnoses or prescribe treatment in any individual. Persons who require such services should consult with a licensed professional. Send mail to ropa@redoakpsychiatry.com with questions or comments about this web site.© 2000 Red Oak Psychiatry Associates, P.A. Updated
11/26/2007
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