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Chemical Name: Thioridazine HCL Trade Name: Mellaril Manufacturer: (of generic): Mylan Pharmaceuticals, Inc. Description: Unknown mechanism of action. A piperdine phenothiazine that probably blocks postsynaptic dopamine receptors in the brain. Indication: Management of the manifestations of psychotic disorders and for the treatment of moderate to marked depression with variable degrees of anxiety in adults, and for the treatment of severe behavioral problems in children marked by combativeness and/or explosive hyperexcitable behavior, and in the short term treatment of hyperactive children who have excessive motor activity with conduct disorder consisting of impulsivity, difficulty sustaining attention, aggressiveness, labile mood, and poor frustration tolerance. Contraindications, Warnings, and Precautions: Contraindicated in severe central nervous system depression or comatose states, as well as hypertensive or hypotensive heart disease of extreme degree. Tardive dyskinesia is a potentially irreversible involuntary movement that may develop. The highest prevalence appears to occur in the elderly, especially women. There is no known treatment, although the syndrome may remit if antipsychotic treatment is withdrawn. The potentially fatal symptom complex of Neurolepic Malignant Syndrome (N.M.S.) has been reported in association with antipsychotic drugs. Signs of N.M.S. may include hyperpryexia, muscle rigidity, altered mental status, irregular pulse or blood pressure, tachychardia, sweating, and cardiac dysrhythmia. Leukopenia and/or agranulocytosis and convulsive seizures have been infrequently reported. Pigmentary retiropathy has been observed primarily in patients taking larger than recommended doses. Adverse Reactions: Possible common side effects may include sedation, orthostatic hypotension, ocular changes, blurred vision, dry mouth, constipation, urinary retention, and mild photosensitivity. Other side effects may include extrapyramidal reactions, dizziness, EEG changes, tachycardia, dark urine, menstrual irregularities, weight gain, and increased appetite. Dosing: Individualized according to the degree of mental and/or emotional disturbance. For children ages 2 - 12 the dose ranges from 0.5 mg to a maximum of 3 mg per kilogram per day. In psychotic adults, the total dose may range from 200 to 800 mg daily in divided doses. |
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These pages are solely for public informational purposes. The information cannot be relied on to make diagnoses or prescribe treatment in any individual. Persons who require such services should consult with a licensed professional. Send mail to ropa@redoakpsychiatry.com with questions or comments about this web site.© 2000 Red Oak Psychiatry Associates, P.A. Updated
11/26/2007
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