Chemical Name:  Estazolam

Brand Name:  ProSom

Manufacturer:  Abbott Laboratories

Description:  Mechanism of action unknown.  A hypnotic agent thought to act on the limbic system and thaluamus of the central nervous system by binding to specific benzodiazepine receptors.

Indications and Use:  For the short term management of insomnia.

Contraindications, Warnings, and Precautions:  Contraindicated in patients with hypersensitivity to drug and during pregnancy.  ProSom may interact with cimetidine, disulfiram, isoniazid, and oral contraceptives.  It may impair the metabolism and clearance of benzodiazepines and prolong their plasma half life. Alcohol use should be avoided with the use of this drug.  Smoking may increase metabolism clearance and decrease plasma half life. Use caution in engaging in hazardous occupations requiring mental alertness.  Withdrawal symptoms have been reported after the abrupt discontinuation of benzodiazepines.  Patients with a history of addiction to drugs or alcohol should be monitored closely because of the risk of habituation and dependence.

Adverse Reactions:  Most common possible side effects may include somnolence, hypokinesia, dizziness and abnormal coordination.

Dosing Range:  Dosing should be 1-2 mg at bedtime. 

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007