Chemical Name:  Pimozide

Trade Name:  Orap

Manufacturer:  Gate Pharmaceuticals

Description:  Orap is a antipsychotic drug.  Mechanism of action is unknown.  Orap is thought to block dopamine nonselectively at both the presynaptic and postsynaptic receptors on neurons in the central nervous system.

Indication:  Orap is indicated for the suppression of motor and phonic tics in patients with Tourette's disorder who failed to respond to standard treatment.  It is not intended for tics that are merely annoying or cosmetically troublesome.

Contraindications, Warnings, and Precautions:  Orap is contraindicated for treatment of tics not associated with Tourette's and should not be used in patients taking drugs which may cause motor and phonic tics until it is determined that the drug, rather than Tourette's is responsible for the tics.  Orap should not be taken in patients with a history of cardiac arrhythmias or congenital long QT syndromes.  The potentially fatal symptom complex of Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs.  Signs of NMS may include hyperpyrexia, muscle rigidity, altered mental status, irregular pulse or blood pressure,  tachycardia, sweating, and cardiac dysrythmias.  Tardve dyskinesia is a potentially irreversible, involuntary movement that may develop.  The highest prevalence appears to occur in the elderly, especially females.  There is no known treatment, although the syndrome may remit if the antipsychotic treatment is withdrawn.

Adverse Reactions:  Possible common side effects may include dry mouth, constipation, and parkinsonian-like symptoms.  Other side effects may include drowsiness, headache,  insomnia, blood pressure changes and visual disturbances.

Dosing Range:  Initial doses in children are typically 0.05 mg per kilogram at bedtime.  Adult doses may be initiated at 1 -2 mg a day given in divided doses.  Doses greater than 0.2 mg per kilogram a day or 10 mg a day are not recommended.

These pages are solely for public informational purposes. The information cannot be relied on to make diagnoses or prescribe treatment in any individual. Persons who require such services should consult with a licensed professional.

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007