Chemical Name:        Maprotiline HCL

Brand Name:              Ludiomil

Manufacturer:           Mylan Pharmaceuticals, Inc. (of generic)

Description:               A tetracyclic antidepressant

Indications and Use:  For the treatment of the symptoms of depression.

Contraindications, Warnings and Precautions:  Contraindicated in persons with seizures.  Do not give concomitantly or within 14 days of monoamine oxidase inhibitors.  Use extreme caution in persons with a history of myocardial infarction and in persons with a history or presence of cardiovascular disease.  Use cautiously in patients with a history of urinary retention, narrow angle glaucoma, or increased intraocular pressure.    Discontinue the drug for as long as clinically feasible prior to any scheduled surgery since the interaction between Ludiomil and general anesthetics is not known.  Do not use with alcohol.  Avoid concomitant use with central nervous system depressants.  The risk of seizures may be increased when Ludiomil is taken with phenothiazines or when the dosage of benzodiazepines is rapidly tapered.  Use caution in patients taking thyroid medication or hyperthyroid patients because of the possibility of enhanced potential for cardiovascular toxicity of Ludiomil.

Adverse Reactions:  Possible side effects may include dizziness, drowsiness nervousness, anxiety, tachycardia, dry mouth, nausea, tremor, constipation, blurred vision, weakness, fatigue and headache.

Dosing Range:  In adults, the initial dose may be 75 mg per day.  Doses above 150mg per day should be exceeded only in the most severely depressed patients to a maximum of 225mg per day.

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© 2000 Red Oak Psychiatry Associates, P.A.    Updated 11/26/2007